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Key attributes of the Toujeo ® SoloStar ® pen: • 95% of new start basal insulin patients rated Toujeo ® SoloStar ® as easy to use after training and 4 weeks of use, in a study 8,a – It is important to train patients on proper product administration • Less injection force 9* aStudy Design: Pen- and insulin-naive T2DM patients inadequately controlled on OADs were enrolled in a 4-week, multicenter, open-label, single-arm, phase 3b study to evaluate the ease of use/ease of learning of the Toujeo ® SoloStar ® pen. On Day 1, patients were trained on use of the device.

Only patients who completed the training and demonstrated a successful injection without assistance were eligible for this study (n=40). Toujeo ® was injected once-daily in the evening. Patients were titrated to a target SMPG of 80-100 mg/dL. Study limitations: potential bias could have been introduced due to the small population and the study's short duration; however, the study was designed to minimize such bias. 8 *Compared with Lantus ® SoloSTAR ®, FlexPen ®, and KwikPen ® in a laboratory environment; doses were not delivered into tissue.

FPG, fasting plasma glucose; NPH, neutral pH. ADA glycemic recommendations for fasting or pre-meal plasma glucose for non-pregnant adults with diabetes: 80-130 mg/dL. More or less stringent goals may be appropriate for individual patients. 10 ADA glycemic recommendations for fasting or pre-meal plasma glucose for non-pregnant adults with diabetes: 80-130 mg/dL.More or less stringent goals may be appropriate for individual patients. 2 In clinical trials, patients started on, or changed to, Toujeo ® required a higher dose than patients controlled with Lantus ®. Ensure patients have a prescription for Toujeo ® as well as a second, separate prescription for pen needles.

References: 1. Toujeo Prescribing Information. Basaglar Prescribing Information.

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Lantus Prescribing Information. Levemir Prescribing Information.

Tresiba Prescribing Information. Toujeo ® SoloStar ® Instructions for Use. Toujeo ® Max SoloStar ® Instructions for Use. Pohlmeier H, Berard L, Brulle-Wohlhueter C, et al. J Diabetes Sci Technol.

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Klonoff D, Nayberg I, Erbstein F, Cali A, Brulle-Wohlhueter C, Haak T. J Diabetes Sci Technol. American Diabetes Association. Diabetes Care. 2017;40(suppl 1):S1-S135.

PLEASE NOTE: This reprint includes information that is not contained within the full prescribing information (PI) for Toujeo ® (insulin glargine injection) 300 Units/mL and is not intended to offer recommendations about Toujeo ® that are inconsistent with the PI. Please read the full indication, the Important Safety Information and the full. Sanofi US does not review the information contained in this website and/or database for content, accuracy, or completeness. Use of and access to this information is subject to the terms, limitations, and conditions set by the website and/or database producer. Sanofi US makes no representation as to the accuracy or any other aspect of the information contained on such website and/or database, nor does Sanofi US necessarily endorse such website and/or database.

Contraindications Toujeo ® is contraindicated during episodes of hypoglycemia and in patients hypersensitive to insulin glargine or any of its excipients. Warnings and Precautions Toujeo ® contains the same active ingredient, insulin glargine, as Lantus ®. The concentration of insulin glargine in Toujeo ® is 300 units per mL. Insulin pens and needles must never be shared between patients. Do NOT reuse needles. Monitor blood glucose in all patients treated with insulin. Modify insulin regimens cautiously and only under medical supervision.

Changes in insulin strength, manufacturer, type, or method of administration may result in the need for a change in insulin dose or an adjustment in concomitant oral antidiabetic treatment. Changes in insulin regimen may result in hyperglycemia or hypoglycemia. Unit for unit, patients started on, or changed to, Toujeo ® required a higher dose than patients controlled with Lantus ®. When changing from another basal insulin to Toujeo ®, patients experienced higher average fasting plasma glucose levels in the first few weeks of therapy until titrated to their individualized fasting plasma glucose targets. Higher doses were required in titrate-to-target studies to achieve glucose control similar to Lantus ®. Download subtitle indonesia thor ragnarok.